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The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations

Athletes considering the Wolverine Stack must check with their sports antidoping organization (such as WADAaligned rules) before starting treatment

Initial treatments may require several injections per week, followed by maintenance doses every month

Human clinical trial data remains limited, with Phase I and II trials for inflammatory bowel disease conducted in the 1990s claiming safety with no toxicity, though full peer-reviewed data never appeared in scientific literature